Lazarus examined the effect of sputum proteases on airway inflammation, and the effect of inflammatory mediators on regulation of airway mucin gene expression and mucin secretion (via the EGF-receptor). In collaboration with Drs John Fahy, George Caughey, and Jay Nadel, Dr. Studies of mast cell mediators led to a series of investigator-initiated clinical research projects to examine the role of leukotrienes in chronic asthma and in mediating the bronchoconstrictor response to inhaled sulfur dioxide the role of tachykinins in mediating the airway hyperresponsiveness, airway inflammation, and symptoms of chronic asthma and the correlation between elastase and elastolytic activity in the sputum of patients with chronic bronchitis and physiological measures of lung function. These cells served as a unique model system for mast cell biology as well as a source of mast cell-derived mediators to examine the role of these mediators in important biological processes. After working in whole animals and organ systems, he developed continuous mastocytoma cell lines that share many important features of normal human mast cells. Lazarus' research has focused on the role of inflammatory cells and mediators in regulating function of the lung and airways in obstructive lung diseases. Currently he is Director of the Training Program in Pulmonary and Critical Care Medicine and Associate Director of the Adult Pulmonary Laboratory. He is an Attending Physician on the Pulmonary Consult Service, the Adult Pulmonary Function Laboratory, and the Chest Faculty Practice at UCSF-Moffitt-Long Hospital, and has been Director of the Chest Faculty Practice, Director of the Medical Specialty Practices, and Interim Chief of the Division of Pulmonary and Critical Care Medicine. Lazarus has directed basic and clinical research on the mechanisms and treatment of asthma, COPD, and other airway diseases. Since joining the faculty at UCSF in 1983, Dr. before returning to UCSF for additional research training in the Cardiovascular Research Institute. Drafted into military service during the Viet Nam era, he spent 2 years as Chief of Pulmonary Medicine and Co-Director of the ICU at Andrews Air Force Base in Washington, D.C. from Irvine, and training in Internal Medicine and Pulmonary & Critical Care Medicine at UCSF. Lazarus is an inbred product of the University of California, having received his A.B.
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